Cancerous carcinoid tumors form in the lining of your gastrointestinal tract and can be caused by certain digestive conditions. The rare tumors are often treated with surgery and medications.
What are carcinoid tumors?
Carcinoid tumors develop when a mutation occurs in the neuroendocrine cells in your digestive system. The dual-purpose cells have both nerve and endocrine features and are capable of producing hormones. Over time, the cancerous cells gradually take over healthy cells and form a tumor. Carcinoid tumors tend to form in the colon, stomach, small intestine or rectum.
Who gets carcinoid tumors?
If anyone in your family has had multiple endocrine neoplasia type 1 syndrome (MEN1) or neurofibromatosis type 1 syndrome (NF1), you may be at greater risk of developing a carcinoid tumor. Your risk also rises if you have Zollinger-Ellison syndrome, pernicious anemia or atrophic gastritis. Older people and women are more likely to develop carcinoid tumors.
What are the symptoms of carcinoid tumors?
There are often no symptoms when a carcinoid tumor is small. In fact, you may only learn that you have a tumor after undergoing a routine colonoscopy or another diagnostic test. Symptoms may occur if the tumor secretes hormones or grows larger. Symptoms depend on the location of the tumor, but may include:
How are carcinoid tumors treated?
Surgery is used to remove all or as much of the tumor as possible. Medications may also be helpful. Depending on your condition, your gastroenterologist may recommend interferon injections that enhance the immune system's ability to attack the tumor or medications that prevent the tumor from releasing hormones.
If your carcinoid tumor has spread to your liver, your gastroenterologist can offer several other treatment options, including cryoablation (freezing) or radiofrequency (heat) treatments to kill the cancer cells. Removing part of the liver during a surgical procedure may be helpful, as can closing off the hepatic artery that feeds the tumor.
Although most gastrointestinal symptoms aren't caused by cancer, it's important to see your gastroenterologist if you experience frequent heartburn, nausea, vomiting, diarrhea, constipation, bloating or other symptoms.
Ulcerative colitis, a type of inflammatory bowel disease, causes painful open sores in your large intestine and rectum. The disease can affect both children and adults. Although there is currently no cure for ulcerative colitis, symptoms can be managed with medications and dietary changes in many cases.
What are the symptoms of ulcerative colitis?
Although symptoms of ulcerative colitis vary depending on the severity of the disease, diarrhea that contains blood or pus is a frequent problem. It may be difficult to get the bathroom in time, particularly if a bout of diarrhea strikes in the middle of the night. Other symptoms can include:
If you have severe ulcerative colitis, you may be more likely to develop one or more serious complications, such as severe dehydration or bleeding, a perforated colon, osteoporosis, megacolon, blood clots or colon cancer.
What are the risk factors for ulcerative colitis?
Ulcerative colitis symptoms usually appear between the ages of 15 and 35. You're more likely to develop ulcerative colitis if other people in your family have it. Your ancestry may also affect your risk. Caucasians and people of Ashkenazi Jewish descent get the disease more often than other ethnic groups.
How is ulcerative colitis treated?
Medications that relieve inflammation and suppress your immune system can be helpful if you have ulcerative colitis. Corticosteroids may also reduce inflammation and bring about a remission of symptoms. Because prolonged use of corticosteroids can cause high blood pressure, diabetes and osteoporosis, they're only recommended for short-term use. Anti-diarrheal medications can reduce the frequency of diarrhea, while iron supplements may prevent anemia caused by bleeding.
Approximately 25 to 40 percent of people who have ulcerative colitis will eventually need surgery to remove the colon, according to the Crohn's and Colitis Foundation. In some cases, your surgeon may be able to connect to your small intestine to your anus, which will allow you to defecate normally. If that's not possible, a bag attached to the abdomen will be used to collect stool.
Ulcerative colitis is a serious inflammatory bowel disease, but it's symptoms can often be managed with medication, dietary changes and stress relief techniques, allowing you to live a fairly normal life.